Manhattan Island is where most of the city's attractions are located, being in the center of the Big Apple is relatively easy, just keep in mind that the Avenues run from north to south in one direction or with some small changes. And the Streets run from West to East. Uptown means to the north or the Bronx and Downtown, refers to Lower Manhattan or Brooklyn. We can find many references that Fifth Avenue and Central Park divide Manhattan between East and West although it is not official many people use it to guide themselves. The streets in the West carry the street number accompanied by the letter W for example 50th Street in the West would appear as W50 St. And the streets in the East are accompanied by the letter E so 50th Street here would appear as E50 St And on the east side of Fifth Avenue we find the avenues: Madison, Park, Lexington, Third, Second and First. To the west side we have the Sixth avenues (sixth) or (also called Avenue of the Americas) Seventh (seven), Eighth, Ninth, Tenth, Eleventh and Twelfth.